Our Investment Focus & Portfolio

Geography

We are open to invest worldwide in innovative early-stage therapeutics and digital health companies, however, due to the location of our offices we focus on North America and Europe/Israel.

United States

  • Abexxa Biologics, Inc.
  • Actym Therapeutics
  • BIVF Office (Boston)
  • BIVF Office (San Francisco)
  • Bodyport, Inc.
  • Libra Therapeutics
  • OncoMyx Therapeutics, Inc.
  • Rgenta
  • Sentien Biotechnologies, Inc.
  • STRM.BIO
  • Wellth, Inc.
  • xCures, Inc.

EU & Switzerland & Israel

  • Abalos Therapeutics GmbH
  • Acousia Therapeutics GmbH
  • Aelin Therapeutics NV
  • Aignostics GmbH
  • Anagenesis Biotechnologies
  • Brainomix, Ltd.
  • DiogenX
  • eTheRNA immunotherapies NV
  • Eyevensys S.A.S.
  • HepaRegenix GmbH
  • Metabomed Ltd.
  • Perfood GmbH
  • Promethera Biosciences S.A./N.V.
  • QUANTRO Therapeutics
  • Rewind Therapeutics N.V.
  • RinRi Therapeutics Ltd.
  • T3 Pharmaceuticals AG
  • T-knife GmbH
  • Topas Therapeutics GmbH

Asia

  • Delonix Bioworks
  • Nuevocor

Boehringer Ingelheim Venture Fund USA Inc.


701 Gateway Bvld.
Suite 440
South San Francisco, CA 94080
USA
Phone: +1 203 7916808
Contact: venture@boehringer-ingelheim.com

Boehringer Ingelheim Venture Fund USA Inc.


1 Broadway
Cambridge, MA 02142
USA
Phone: +1 203 7916808
Contact: venture@boehringer-ingelheim.com

Boehringer Ingelheim Venture Fund GmbH


Binger Straße 173
55216 Ingelheim am Rhein
GERMANY
Phone: +49 6132 77-181170
Contact: venture@boehringer-ingelheim.com

Bodyport Inc

Bodyport Inc

Bodyport’s mission is to prevent and ultimately eliminate heart disease by empowering every person with high quality, actionable health information in their home.

Year of investment: 2019; BIVF Board Representative: Debbie Lin
www.bodyport.com

Abexxa Biologics, Inc.

Abexxa Biologics, Inc.

Abexxa Biologics, Inc. is a research-stage bio-pharmaceutical company focused on discovering and developing breakthrough antibody-based drugs to its proprietary class of targets designed to revolutionize cancer treatments by providing highly effective targeted therapies. The foundation of the company’s technology is based on more than 25 years’ experience in novel immunotherapy research. AbeXXa is based in Arlington, TX.

Year of investment: 2016; BIVF Board Representative: Fei Shen
www.abexxa.com

Acousia Therapeutics GmbH

Acousia Therapeutics GmbH

Acousia Therapeutics GmbH is a privately held biotech company based in Tübingen, Germany, dedicated to identify small molecules for an innovative treatment of hearing loss. The new therapeutic approach will replace lost sensory hair cells, the key cells for hearing in the inner ear, by cellular regeneration originating from supporting cells. Acousia will develop drugs for local application, which will restore hearing in patients who have lost their hearing ability due to various reasons, e.g. noise trauma, treatment with ototoxic drugs or sudden deafness. In addition, this therapy will have the potential to treat the age-related decrease in hearing capacity.

Year of investment: 2012; BIVF Board Representative: Frank Kalkbrenner
www.acousia.com

HepaRegenix GmbH

HepaRegenix GmbH

HepaRegenix GmbH, founded in 2016, is a spin-off out of the University of Tübingen (Germany). The pioneering discovery of Prof. Lars Zender, that the inhibition of the MAP kinase kinase MKK4 leads to an overall increased capacity of liver cell regeneration, attracted a very inter-disciplinary team of experienced drug discovery seniors into HepaRegenix. The company develops a small chemical compound for the treatment of acute, chronic and/or acute-on-chronic liver failure. An upside will be the development for NASH as 2nd step, dependent on thorough pre-clinical characterization of the underlying molecular mechanism of action.

Year of investment: 2016; BIVF Board Representative: Johannes Zanzinger
www.heparegenix.com

Rewind Therapeutics

Rewind Therapeutics

Rewind Therapeutics is developing first-in-class therapies for myelin-related diseases and aims to bring them into fast-track clinical development.
The Company was founded by KU Leuven’s Centre for Drug Design and Discovery (CD3) and Axxam S.p.A. (Milano, Italy). Rewind Therapeutics works in close collaboration with both organisations and a world-class academic network to advance its discovery and development activities. Rewind Therapeutics completed a €15.2 million Series A financing in January 2018, which was led by Boehringer Ingelheim Venture Fund, M Ventures BV and the Flemish investment company PMV, together with CD3 and KU Leuven Gemma Frisius Fonds.

Year of investment: 2017; BIVF Board Representative: Sebastian Kreuz
www.rewindtherapeutics.com

Aelin Therapeutics

Aelin Therapeutics

The company pioneers a novel modality in drug development to develop a complete new class of antibiotics and first in class therapeutics against high value typical undruggable human targets. The technology, branded Pept-insTM, harnesses the power of protein aggregation to specifically induce a functional knockdown of a target protein. Aelin Therapeutics was founded by VIB and its partner universities KU Leuven, VUB, UGent, based on the ground-breaking work of renowned structural biologists Prof Joost Schymkowitz and Prof Frederic Rousseau. Aelin Therapeutics raised €27 million in a Series A financing round in December 2017 with a strong investor syndicate including LSP (the Netherlands), PMV (Belgium), Novartis Venture Fund (Switzerland), Boehringer Ingelheim Venture Fund (Germany) and Fund+ (Belgium).

Year of investment: 2017; BIVF Board Representative: Frank Kalkbrenner
www.aelintx.com

Brainomix, Ltd.

Brainomix, Ltd.

Brainomix, Ltd. focuses on imaging software for neurological and cerebrovascular diseases and developed a software tool (e-ASPECTS) for the automated analysis of CT scans to detect early ischemic changes in the brain of patients with clinical signs of stroke. Brainomix is a spin-out from the University of Oxford, UK.

Year of investment: 2018; BIVF Board Representative: Frank Kalkbrenner
www.brainomix.com

eTheRNA immunotherapies NV

eTheRNA immunotherapies NV

eTheRNA immunotherapies NV is a spin-off from the Brussels university 'Vrije Universiteit Brussel' (VUB), Belgium. The company continues the development of its proprietary TriMix mRNA-based immunotherapies for melanoma, breast cancer and infectious diseases. This mRNA-based technology focuses on enhancing and modulating dendritic cells which fulfill a fundamental role in eliciting the human immune response to cancer and infectious diseases.

Year of investment: 2016; BIVF Board Representative: Frank Kalkbrenner
www.etherna.be

Eyevensys S.A.S.

Eyevensys S.A.S.

Eyevensys S.A.S. is a developer of a new non-viral gene therapy process to treat ocular illnesses. The new process enables prolonged production of therapeutic proteins through injection and electrotransfer of expression plasmids into the ciliar muscle and is aimed at treating uveitis and AMD. In stage two, Eyevensys will focus on treating more common conditions such as diabetic retinopathy.The company was founded in Paris (France) in 2009 by Francine Behar-Cohen, professor of medicine at Paris Descartes University, head of ophthalmology at l'Hotel Dieu.

Year of investment: 2013; BIVF Board Representative: Johannes Zanzinger
www.eyevensys.com

Anagenesis Biotechnologies

Anagenesis Biotechnologies

Anagenesis Biotechnologies is a Strasbourg based Biotech company, operational since 2014. Anagenesis is a preclinical‐stage company focused on developing novel treatments for genetic and age-related muscle degenerative diseases. They own a proprietary platform technology, to guide the differentiation of pluripotent stem cells (iPSC) into Paraxial Mesoderm Multipotent Cells (P2MCs), which are the shared precursors of various tissues, such as skeletal muscle, ribs, vertebrae, dermis, endothelium & brown fat. The method originated in the lab of Olivier Pourquié, a world expert in the field of stem cells and muscle development. Based on P2MC progenitor cells, the company has developed proprietary know how, to mimic the natural process of muscle formation (myogenesis) and has set up a high throughput screening assay to identify compounds activating the P2MC cells to generate skeletal muscle tissue. A second indication focus of Anagenesis is the differentiation of P2MC`s to generate Brown Adipocyte Tissue (BAT), as a potential treatment for metabolic diseases, such as diabetes or obesity.

Year of investment: 2019; IVF Board Representative: Niklas Czeloth
www.anagenesis-biotech.com

Imcheck Therapeutics SAS

Imcheck Therapeutics SAS

Imcheck Therapeutics SAS, founded in 2015, is a spin-off from the Institute Paoli Calmettes in Marseilles (France). Developing innovative antibody therapeutics in the field of immuno-oncology, Imcheck Therapeutics translates the pioneering work of Prof. Daniel Olive focussing on novel checkpoint principles directly in the interplay of the innate and adaptive immune response. The team of highly motivated entrepreneurs builds on the break-through developments around PD-1, as well as CTLA-4 specific antibodies to release evasion of tumor cells from immune surveillance. Imcheck Therapeutics will focus on a proprietory group of targets to integrate the power of γδ-T cells (innate) with the of αβ-T cells (adaptive) to significantly improve the response and clinical outcome of modern immunotherapy approaches for hematological and as well as for solid tumor indications.

Year of investment: 2015; BIVF Board Representative: Philipp Müller
www.imchecktherapeutics.com

DiogenX

DiogenX

DiogenX specializes in the development of pancreatic beta cell modulators for the treatment of Type 1 (T1D) and Type 2 Diabetes (T2D). The company’s lead asset is a protein capable of regenerating in vivo a functional pancreatic beta cell mass, potentially offering patients clear benefits in terms of both survival rates and quality of life. DiogenX is based in Marseille, France with labs in Nice. Its asset originated from Dr. Patrick Collombat’s laboratory (Inserm, CNRS, Nice University).

Year of investment: 2020; BIVF Board Representative: Johannes Zanzinger
www.diogenx.com

Metabomed Ltd.

Metabomed Ltd.

Metabomed Ltd. is an Israeli based newly created biotech company focused on the identifications of novel targets in the field of cancer metabolism. Based on its proprietary interdisciplinary target identification platform, Metabomed’s approach has great potential to identify new targets that form a synthetic lethal gene pair with metabolic genes inactivated in cancer cells. Inhibition of these targets results in toxic effects specific to cancer cells, with potential sparing of normal cells. The company will subsequently focus on the discovery of novel small molecule drugs directed against such targets.

Year of investment: 2014; BIVF Board Representative: Johannes Zanzinger
www.metabomed.com

Perfood GmbH

Perfood GmbH

Perfood analyzes glycemic responses to meals, activity, symptoms, medication and gut microbiome on the basis of machine learning algorithms. This results in a pipeline of digital therapeutics based on personalized low-glycemic diet. At the same time, Perfood builds up a rich dataset for phenotyping.

Year of investment: 2020; BIVF Board Representative: Oliver Reuß
www.perfood.de

T3 Pharmaceuticals AG

T3 Pharmaceuticals AG

The vision of T3 Pharmaceuticals is to improve the lives of cancer patients with highly innovative treatments. Despite significant advances of classical therapies, there remains a high need for novel and innovative medicines to treat cancer. T3 Pharmaceuticals is dedicated to filling this gap by developing highly specific and efficient treatments using live bacteria.
T3 Pharmaceuticals was founded in May 2015 by Simon Ittig, Christoph Kasper, Marlise Amstutz and Helmut Kessmann as a spin-off of the University of Basel. The team has developed an efficient protein delivery technology that is based on the use of live bacteria. While the technology has diverse applications in research, T3 Pharma has further developed the system to serve as a novel therapeutic to treat solid tumors.

Year of investment: 2019; BIVF Board Representative: Frank Kalkbrenner
www.t3pharma.com/company

Promethera Biosciences

Promethera Biosciences

Promethera Biosciences S.A./N.V.' mission is to develop an allogenic cell therapy approach to treat inborn metabolic liver diseases. The defect of one enzyme can lead to a life-threatening disease with short life expectation and low quality of life. Liver transplantation is often the only treatment option and very much limited due to the scarcity of matching organs and the transplantation risk. Promethera Biosciences addresses this high unmet medical need with their proprietary new progenitor cell type called HepaStem®, consisting of Heterologous human Adult Liver Progenitor Cell (hHALPC), which in pre-clinical experiments has shown the potential to overcome limitations of mature hepatocyte therapy. Promethera is a Belgian company and has started phase I/II clinical studies in March 2012.

Year of investment: 2012; Former BIVF Board Representative: Ilka Wicke (until 2018)
www.promethera.com

Sentien Biotechnologies, Inc.

Sentien Biotechnologies, Inc.

Sentien Biotechnologies, Inc. is a preclinical stage company developing novel approaches to cell therapy. The lead product utilizes dialysis as a drug delivery system to administer the therapeutic factors secreted from mesenchymal stem cells (MSCs), which dynamically secrete factors to modulate inflammation, prevent epithelial cell death, and promote regeneration. As applied to their first indication of severe Acute Kidney Injury, (AKI), this lead product integrates seamlessly with existing standard of care, transforming dialysis from a passive, last resort option into an active therapy that can reverse the course of disease. This approach can rapidly extend into other disease where extracorporeal support is indicated, such as Acute Liver Failure, Acute Respiratory Distress Syndrome, and Chronic Kidney Disease. Sentien is based in Medford, MA.

Year of investment: 2015; BIVF Board Representative: Kanad Das
www.sentienbiotech.com

OncoMyx Therapeutics, Inc.

OncoMyx Therapeutics, Inc.

OncoMyx Therapeutics is developing oncolytic immunotherapies based on the myxoma virus (MYXV) platform to orchestrate an immune response and treat cancer. Successful immuno-oncology (IO) cancer treatment generally requires combination therapy, and oncolytic viruses (OVs) have emerged as a safe and effective IO complement.
Their MYXV platform, spun-out from Arizona State University (ASU), is poised to be a best-in-class OV approach. They have assembled the top OV team around MYXV to advance a pipeline of oncology therapeutics for the benefit of cancer patients.

Year of investment: 2019, BIVF Board Representative: Kanad Das
www.oncomyx.com

Topas Therapeutics

Topas Therapeutics

Topas Therapeutics is a private Hamburg-based biotechnology company focused on developing peptide-loaded nanoparticles to address immuno-tolerization of major unmet clinical need, including autoimmune diseases, allergies and anti-drug antibodies. Topas’ technology platform induces antigen-specific immune tolerance by harnessing the liver’s natural immuno-tolerizing capabilities.

Year of investment: 2017; BIVF Board Representative: Sebastian Kreuz
www.topas-therapeutics.com/topas/home/

Wellth

Wellth

Wellth, Inc. applies behavioral economics through a mobile first, financial incentive focused behavior change platform to achieve better adherence, engagement, and health. The solution serves the most common chronic conditions. Wellth is headquartered in Brooklyn, NY.

Year of investment: 2018; BIVF Board Representative: Debbie Lin
www.wellthapp.com

Libra Therapeutics

Libra Therapeutics

Libra Therapeutics is focused on developing novel disease-modifying therapeutics that can restore the cellular balance disrupted in neurodegenerative diseases. These include amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's, Parkinson's, and Huntington's disease, which are all characterized by cellular disequilibrium caused by the production and decreased clearance of neurotoxic proteins. The company’s therapeutic platform is uniquely positioned to discover and develop small molecule drugs with distinct molecular approaches that can 1) increase autophagy to more rapidly clear toxic proteins and 2) attenuate the production of neurotoxic proteins.

Year of investment: 2020; BIVF Board Representative: Kanad Das
www.libratherapeutics.com

RinRi Therapeutics Ltd.

RinRi Therapeutics Ltd.

RinRi Therapeutics Ltd. was incorporated in November 2018 by Prof. Dr. Marcelo Rivolta and the University of Sheffield. RinRi develops a cellular Advanced Therapy Medicinal Product (ATMP) using pre-determined human embryonic stem cells towards first-in-men trials for implantation into the cochlear of patients suffering from sensorineural hearing loss. RinRi is based in Sheffield, UK.

Year of investment: 2019; BIVF Board Representative: Frank Kalkbrenner
www.rinri-therapeutics.com/

Abalos Therapeutics GmbH

Abalos Therapeutics GmbH

Abalos Therapeutics has harnessed the unique immune stimulation of the arenavirus to develop a novel anti-cancer approach that provides the full breadth of the immune system’s power specifically against cancer cells. Through viral replication within cancer cells, Abalos’ arenavirus-based drug candidates are designed to awake precise immune responses and activate all relevant immune cell types against primary tumors and metastases. Led by experienced biotech entrepreneurs and immunology pioneers, Abalos’ goal is to achieve a quantum leap in immuno-oncology.

Year of investment: 2019; BIVF Board Representative: Sebastian Kreuz
www.abalos-tx.com

Actym Therapeutics

Actym Therapeutics

Actym Therapeutics is an immunotherapy company that aims to discover and develop attenuated Salmonella Typhimurium strains as a systemic delivery agent to allow for local expression of multiple therapeutic proteins selectively in the tumor microenvironment for the treatment of solid tumor indication(s). Actym's technology platform is designed to harness the body's natural immune system to modify the tumor microenvironment and allows for targeting immune pathways that are intractable using conventional small molecule or antibody-based therapeutics.

Year of investment: 2020; BIVF Board Representative: Kanad Das
www.actymthera.com

Rgenta

Rgenta

Rgenta is developing a pipeline of oral, small-molecule RNA-targeting medicines with an initial focus on oncology and neurological disorders. The company’s proprietary platform mines the massive genomics data to identify targetable RNA processing events and design small-molecule glues to modulate the interactions among the spliceosome, regulatory proteins, and RNAs. Rgenta’s lead programs and unique approach are unlocking the therapeutic potential of historically undruggable targets in human diseases.

Year of investment: 2020; BIVF Board Representative: Fei Shen
www.rgentatx.com

Aignostics GmbH

Aignostics

Aignostics, a spin-off from Charité – Universitätsmedizin Berlin and the Berlin Institute of Health, is pioneering computational pathology for pharmaceutical research and diagnostics. Its proprietary "Explainable AI" platform draws on research from Fraunhofer Society, Charité, and TU Berlin to overcome the typical "black-box" problem of AI in pathology. Aignostics' focus lies on developing bespoke AI models for clinical trials and CDx development.

Year of investment: 2020; BIVF Board Representative: Alexander Ehlgen
www.aignostics.com

Tacalyx GmbH

Tacalyx GmbH

Founded in 2019, Tacalyx GmbH is a spin-off out of the Max-Planck-Institute of Colloids and Interfaces in Potsdam, Germany. The Department of Biomolecular Systems led by Prof. Dr. Peter H. Seeberger pioneered the chemical synthesis of ultrapure cancer-associated carbohydrate antigens (TACA) for the generation of high-affinity and selective antibody scaffolds. Tacalyx will profile the antibody panels for functional modulation of tumor cells and/or immune cells in the tumor micro-environment. Antibodies with functional modulating, as well as drug like properties will be developed for towards clinical testing in various solid tumor indications.

Year of investment: 2019; BIVF Board Representative: Alexander Ehlgen
www.tacalyx.com

Dopavision GmbH

Dopavision GmbH

Dopavision GmbH is developing a digital therapeutic for myopia which can be seamlessly and invisibly integrated while using a smartphone. The technology projects a light stimulus from a screen (e.g., a smartphone) into the eye to activate a neurotransmitter cascade which influences the correct development of the eyeball and thereby correct vision. Dopavision is headquartered in Berlin, Germany.

Year of investment: 2019; BIVF Board Representative: Oliver Reuß
www.dopavision.com

T-knife GmbH

T-knife GmbH

T-knife GmbH is a spin-off of the Max-Delbrück-Center (MDC) founded in 2015 by Prof. Thomas Blankenstein. Derived from T-knife’s proprietary Humanized TCR Mice, the Berlin-based Biotech company develops T cell receptors (TCR) for adoptive T cell therapy. The Humanized TCR mice carry the entire human TCRαβ gene loci and recombine a broad repertoire of fully human TCRs. In addition, the transgenic expression of human HLA molecules allows ‘human-like’ presentation of antigens via the transgenic HLA to the fully human TCRs. This technology allows highly efficient generation and selection of TCRs for virtually any human tumor antigen. Since the mouse immune system is not tolerant to most human cancer antigens the obtained TCRs are expected to show optimal affinity for cancer therapy. The company has a broad expertise in tumor target selection, TCR sequence isolation and optimization, transgenic TCR expression and characterization. A clinical phase I trial with T-knife´s TCR lead candidate targeting MAGE-A1 for patients with multiple myeloma will start recruiting in 2019 in cooperation with Charité. T-knife is based in Berlin, Germany.

Year of investment: 2019; BIVF Board Representative: Frank Kalkbrenner

QUANTRO Therapeutics

quantro

QUANTRO will combine and exploit innovative technologies in the areas of functional-genetics and transcriptomics to generate an unprecedented cancer drug discovery pipeline transforming the precision and scope of cell-based compound screens.

Year of investment: 2020; BIVF Board Representative: Sebastian Kreuz
www.quantro-tx.com

Delonix Bioworks

Delonix

Delonix Bioworks is a biotech company leveraging synthetic biology approaches and gene editing to develop the next generation medical solutions to infectious diseases and cancer. The company’s research programs focus on rational design and programming of bacteria as living medicines.

Year of investment: 2021; BIVF Board Representative: Weiyi Zhang

Nuevocor

Nuevocor

Headquartered in Singapore, Nuevocor focuses on developing AAV gene therapy vectors bearing therapeutic cargo for the treatment of genetically defined cardiac diseases with high unmet need. Leveraging its novel target discovery platform, and a genetic modifier approach to gene therapy, Nuevocor aims to meaningfully improve the quality of life for patients with presently incurable genetic heart disease.

Year of investment: 2021; BIVF Board Representative: Weiyi Zhang
www.nuevocor.com

STRM.BIO

STRM.BIO

STRM.BIO is a pre-clinical, VC-backed biotechnology company that is leveraging extracellular vesicles (EVs) to deliver gene therapies in vivo. At STRM.BIO, we are developing a better way to deliver gene therapy: simpler, safer, affordable. Our proprietary EV platform is designed to bring treatment directly to the patient, without the complexity and side effects of virus-based, ex-vivo processes – still the most common. And our approach to EVs will make it easier to scale up manufacturing and bring costs down. Our work will lead to new treatments and make existing ones more effective, opening the door to the future of medicine to patients fighting rare diseases worldwide.

Year of investment: 2021; BIVF Board Representative: Fei Shen
www.strm.bio

xCures, Inc.

xCures, Inc.

The xCures platform transforms complex unstructured medical data directly from the patient’s medical records into structured data suitable for analysis and machine learning. Our A.I. engine then actively cross-references this data against the vast digital library of oncology data to match patients with potential treatments and predict outcomes. This empowers patients and their oncologists to make more informed and effective treatment decisions.

Year of investment: 2021; BIVF Board Representative: Mark Ralph
www.xcures.com